TUBB4A (tubulin beta 4A class IVa)

2016-10-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
DYT4,TUBB4,beta-5
FUSION GENES

Other Information

Locus ID:

NCBI: 10382
MIM: 602662
HGNC: 20774
Ensembl: ENSG00000104833

Variants:

dbSNP: 10382
ClinVar: 10382
TCGA: ENSG00000104833
COSMIC: TUBB4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104833ENST00000264071P04350
ENSG00000104833ENST00000594075M0QYM7
ENSG00000104833ENST00000594276M0R2D3
ENSG00000104833ENST00000594290M0R0X0
ENSG00000104833ENST00000595324M0QY37
ENSG00000104833ENST00000596291M0R1I1
ENSG00000104833ENST00000596926M0QX14
ENSG00000104833ENST00000597686M0R278
ENSG00000104833ENST00000598006M0R2T4
ENSG00000104833ENST00000598635M0QZL7
ENSG00000104833ENST00000600216M0R042
ENSG00000104833ENST00000601152M0R0M1
ENSG00000104833ENST00000601640M0QY85

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387629262024Expanding the phenotypic and genotypic spectrum of DYT-TUBB4A with seven patients from India.0
387629262024Expanding the phenotypic and genotypic spectrum of DYT-TUBB4A with seven patients from India.0
358712122023Novel TUBB4A mutation in a family with hereditary spastic paraplegia.0
369729302023[Analysis of TUBB4A gene variant in a patient with adolescent-onset hypomyelinating leukodystrophy with atrophy of basal ganglia and cerebellum].0
375299382023Mutation in the β-tubulin gene TUBB4A results in epileptic encephalopathy associated with hypomyelinated leucodystrophy: Unexpected findings reveal genetic mosaicism.0
358712122023Novel TUBB4A mutation in a family with hereditary spastic paraplegia.0
369729302023[Analysis of TUBB4A gene variant in a patient with adolescent-onset hypomyelinating leukodystrophy with atrophy of basal ganglia and cerebellum].0
375299382023Mutation in the β-tubulin gene TUBB4A results in epileptic encephalopathy associated with hypomyelinated leucodystrophy: Unexpected findings reveal genetic mosaicism.0
349971442022In-silico phenotype prediction by normal mode variant analysis in TUBB4A-related disease.1
352757272022H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects.5
355897072022TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling.15
349971442022In-silico phenotype prediction by normal mode variant analysis in TUBB4A-related disease.1
352757272022H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects.5
355897072022TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling.15
329434872021DYT-TUBB4A (DYT4 Dystonia): New Clinical and Genetic Observations.6

Citation

Dessen P

TUBB4A (tubulin beta 4A class IVa)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56600/tubb4a-(tubulin-beta-4a-class-iva)