Identity
HGNC
LOCATION
Yq11.223
LOCUSID
ALIAS
HY,HYA,JARID1D,SMCY
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8284
MIM: 426000
HGNC: 11115
Ensembl: ENSG00000012817
Variants:
dbSNP: 8284
ClinVar: 8284
TCGA: ENSG00000012817
COSMIC: KDM5D
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37344599 | 2023 | Histone demethylase KDM5D upregulation drives sex differences in colon cancer. | 20 |
| 37344599 | 2023 | Histone demethylase KDM5D upregulation drives sex differences in colon cancer. | 20 |
| 34127738 | 2021 | Y disruption, autosomal hypomethylation and poor male lung cancer survival. | 14 |
| 34688635 | 2021 | KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. | 10 |
| 34127738 | 2021 | Y disruption, autosomal hypomethylation and poor male lung cancer survival. | 14 |
| 34688635 | 2021 | KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. | 10 |
| 32196595 | 2020 | ETV4 promotes the progression of gastric cancer through regulating KDM5D. | 9 |
| 32732223 | 2020 | X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. | 21 |
| 33040644 | 2020 | Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells. | 4 |
| 32196595 | 2020 | ETV4 promotes the progression of gastric cancer through regulating KDM5D. | 9 |
| 32732223 | 2020 | X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. | 21 |
| 33040644 | 2020 | Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells. | 4 |
| 30826357 | 2019 | Proteomics based identification of KDM5 histone demethylases associated with cardiovascular disease. | 12 |
| 30864186 | 2019 | KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. | 13 |
| 31560558 | 2019 | Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation. | 15 |
Citation
Dessen P
KDM5D (lysine demethylase 5D)
Atlas Genet Cytogenet Oncol Haematol. 2016-10-01
Online version: http://atlasgeneticsoncology.org/gene/56630/kdm5d-(lysine-demethylase-5d)
