SLC25A6 (solute carrier family 25 member 6)

2016-12-01  

Identity

HGNC
SLC25A6
LOCATION
Xp22.33
LOCUSID
293
ALIAS
AAC3,ANT,ANT 2,ANT 3,ANT3,ANT3Y

Other Information

Locus ID:

NCBI: 293
MIM: 403000
HGNC: 10992
Ensembl: ENSG00000169100

Variants:

dbSNP: 293
ClinVar: 293
TCGA: ENSG00000169100
COSMIC: SLC25A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169100ENST00000381401P12236
ENSG00000169100ENST00000381401Q6I9V5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Vpr with host cellular proteinsREACTOMER-HSA-176033
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilizationREACTOMER-HSA-180897
Influenza InfectionREACTOMER-HSA-168254
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
Influenza Virus Induced ApoptosisREACTOMER-HSA-168277
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374956502023Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.0
374956502023Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.0
321567822020Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.19
333966582020Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.7
321567822020Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.19
333966582020Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.7
268420672016Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.4
268420672016Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.4
262123612015Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.0
262123612015Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.0
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
196698102010Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach.9
196698102010Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach.9
191115452009Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells.3

Citation

Dessen P

SLC25A6 (solute carrier family 25 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56647/slc25a6-(solute-carrier-family-25-member-6)