Identity
HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
AZK,CNM6,MLK7,MLT,MLTK,MLTKalpha,MLTKbeta,MRK,SFMMP,ZAK,mlklak,pk
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51776
MIM: 609479
HGNC: 17797
Ensembl: ENSG00000091436
Variants:
dbSNP: 51776
ClinVar: 51776
TCGA: ENSG00000091436
COSMIC: MAP3K20
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK signaling pathway | KEGG | ko04010 |
| MAPK signaling pathway | KEGG | hsa04010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38451290 | 2024 | Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies. | 0 |
| 38451290 | 2024 | Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies. | 0 |
| 37427997 | 2023 | Myofibrillar myopathy hallmarks associated with ZAK deficiency. | 0 |
| 37427997 | 2023 | Myofibrillar myopathy hallmarks associated with ZAK deficiency. | 0 |
| 33620708 | 2022 | ZAK Gene Expression in Patients with Helicobacter pylori Infection. | 0 |
| 35276386 | 2022 | Targeted inhibition of ZAK ameliorates renal interstitial fibrosis. | 4 |
| 35857590 | 2022 | ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome. | 39 |
| 33620708 | 2022 | ZAK Gene Expression in Patients with Helicobacter pylori Infection. | 0 |
| 35276386 | 2022 | Targeted inhibition of ZAK ameliorates renal interstitial fibrosis. | 4 |
| 35857590 | 2022 | ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome. | 39 |
| 32397561 | 2020 | Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation. | 1 |
| 32521851 | 2020 | MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2. | 3 |
| 32397561 | 2020 | Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation. | 1 |
| 32521851 | 2020 | MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2. | 3 |
| 30535460 | 2019 | Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression. | 6 |
Citation
Dessen P
MAP3K20 (mitogen-activated protein kinase kinase kinase 20)
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/gene/56651/map3k20-(mitogen-activated-protein-kinase-kinase-kinase-20)
