NPY4R (neuropeptide Y receptor Y4)

2016-12-01  

Identity

HGNC
NPY4R
LOCATION
10q11.22
LOCUSID
5540
ALIAS
NPY4-R,PP1,PPYR1,Y4

Other Information

Locus ID:

NCBI: 5540
MIM: 601790
HGNC: 9329
Ensembl: ENSG00000204174

Variants:

dbSNP: 5540
ClinVar: 5540
TCGA: ENSG00000204174
COSMIC: NPY4R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204174ENST00000374312P50391
ENSG00000204174ENST00000612632P50391

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337829202021Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.4
337829202021Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.4
296212592018Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference.5
296212592018Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference.5
278182912017C-terminal motif of human neuropeptide Y(4) receptor determines internalization and arrestin recruitment.3
278182912017C-terminal motif of human neuropeptide Y(4) receptor determines internalization and arrestin recruitment.3
265757902016Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC.16
269212182016CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity.13
265757902016Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC.16
269212182016CNV analysis and mutation screening indicate an important role for the NPY4R gene in human obesity.13
254457122015Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.20
254457122015Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.20
243754092014Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.9
243754092014Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket.9
229479432012Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G-protein-coupled receptors.3

Citation

Dessen P

NPY4R (neuropeptide Y receptor Y4)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56655/npy4r-(neuropeptide-y-receptor-y4)