Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 205
MIM: 103030
HGNC: 363
Ensembl: ENSG00000162433
Variants:
dbSNP: 205
ClinVar: 205
TCGA: ENSG00000162433
COSMIC: AK4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162433 | ENST00000327299 | P27144 |
| ENSG00000162433 | ENST00000395334 | P27144 |
| ENSG00000162433 | ENST00000545314 | P27144 |
| ENSG00000162433 | ENST00000546702 | D3DQ64 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10005 | adefovir dipivoxil | Chemical | Pathway | associated | |||
| PA10204 | tenofovir | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33361582 | 2021 | MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3. | 7 |
| 34638712 | 2021 | Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways. | 9 |
| 33361582 | 2021 | MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3. | 7 |
| 34638712 | 2021 | Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways. | 9 |
| 31931771 | 2020 | Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis. | 27 |
| 32956623 | 2020 | Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. | 46 |
| 31931771 | 2020 | Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis. | 27 |
| 32956623 | 2020 | Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. | 46 |
| 30696468 | 2019 | Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. | 38 |
| 31444368 | 2019 | A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. | 19 |
| 31463832 | 2019 | Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion. | 14 |
| 31827645 | 2019 | AK4 Promotes the Progression of HER2-Positive Breast Cancer by Facilitating Cell Proliferation and Invasion. | 10 |
| 30696468 | 2019 | Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. | 38 |
| 31444368 | 2019 | A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. | 19 |
| 31463832 | 2019 | Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion. | 14 |
Citation
Dessen P
AK4 (adenylate kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/gene/56660/ak4-(adenylate-kinase-4)
