SLC18A1 (solute carrier family 18 member A1)

2016-12-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
CGAT,VAT1,VMAT1

Other Information

Locus ID:

NCBI: 6570
MIM: 193002
HGNC: 10934
Ensembl: ENSG00000036565

Variants:

dbSNP: 6570
ClinVar: 6570
TCGA: ENSG00000036565
COSMIC: SLC18A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000036565ENST00000265808P54219
ENSG00000036565ENST00000276373P54219
ENSG00000036565ENST00000381608P54219
ENSG00000036565ENST00000437980P54219
ENSG00000036565ENST00000440926P54219
ENSG00000036565ENST00000517776Q96GL6
ENSG00000036565ENST00000519026P54219
ENSG00000036565ENST00000522513E5RK12

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
355247722022Sclerosing Paragangliomas: Correlations of Histological Features with Patients' Genotype and Vesicular Monoamine Transporter Expression.0
355247722022Sclerosing Paragangliomas: Correlations of Histological Features with Patients' Genotype and Vesicular Monoamine Transporter Expression.0
306568522019Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states.5
313174762019Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma.3
317912322019Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.3
306568522019Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states.5
313174762019Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma.3
317912322019Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.3
295363332018Association Study of VMAT1 Polymorphisms and Suicide Behavior.0
296027292018Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.5
299985432018Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.17
301940792018Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (SLC18A1) in Lung Cancer.4
295363332018Association Study of VMAT1 Polymorphisms and Suicide Behavior.0
296027292018Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.5
299985432018Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake.17

Citation

Dessen P

SLC18A1 (solute carrier family 18 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56662/slc18a1-(solute-carrier-family-18-member-a1)