SRP19 (signal recognition particle 19)

2016-12-01 Affiliation

Identity

HGNC

SRP19

LOCATION

5q22.2

LOCUSID

6728

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6728
MIM: 182175
HGNC: 11300
Ensembl: ENSG00000153037

Variants:

dbSNP: 6728
ClinVar: 6728
TCGA: ENSG00000153037
COSMIC: SRP19

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000153037	ENST00000282999	P09132
ENSG00000153037	ENST00000391338	A0A2U3TZN1
ENSG00000153037	ENST00000445150	A0A087WWU9
ENSG00000153037	ENST00000503445	A0A2R8Y4M3
ENSG00000153037	ENST00000505459	P09132
ENSG00000153037	ENST00000506997	D6RBG4
ENSG00000153037	ENST00000515463	P09132
ENSG00000153037	ENST00000621420	A0A087WYR0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein export	KEGG	ko03060
Protein export	KEGG	hsa03060
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Gene Expression	REACTOME	R-HSA-74160

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	22795047
PA449015	citalopram	Chemical	ClinicalAnnotation	associated	PD	22795047
PA449673	fluoxetine	Chemical	ClinicalAnnotation	associated	PD	22795047
PA450801	paroxetine	Chemical	ClinicalAnnotation	associated	PD	22795047
PA451333	sertraline	Chemical	ClinicalAnnotation	associated	PD	22795047

References

Pubmed ID	Year	Title	Citations
36223592	2023	Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.	8
36223592	2023	Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.	8
27899666	2017	Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.	17
27899666	2017	Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.	17
27525944	2016	Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy.	5
27525944	2016	Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy.	5
20179341	2010	Structural insights into the assembly of the human and archaeal signal recognition particles.	7
20179341	2010	Structural insights into the assembly of the human and archaeal signal recognition particles.	7
17434535	2007	A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.	8
17434535	2007	A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.	8
12050674	2002	Structure of the SRP19 RNA complex and implications for signal recognition particle assembly.	44
12244299	2002	Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.	43
12050674	2002	Structure of the SRP19 RNA complex and implications for signal recognition particle assembly.	44
12244299	2002	Induced structural changes of 7SL RNA during the assembly of human signal recognition particle.	43
11641499	2001	Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.	29

Citation

Dessen P

SRP19 (signal recognition particle 19)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56668/srp19-(signal-recognition-particle-19)