Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84451
MIM: 614793
HGNC: 29798
Ensembl: ENSG00000143674
Variants:
dbSNP: 84451
ClinVar: 84451
TCGA: ENSG00000143674
COSMIC: MAP3K21
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143674 | ENST00000366622 | Q5TCX8 |
| ENSG00000143674 | ENST00000366623 | Q5TCX8 |
| ENSG00000143674 | ENST00000366624 | Q5TCX8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK (JNK) signaling | KEGG | hsa_M00688 |
| MAPK (p38) signaling | KEGG | hsa_M00689 |
| MAPK (JNK) signaling | KEGG | M00688 |
| MAPK (p38) signaling | KEGG | M00689 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37594950 | 2023 | MLK4 as an immune marker and its correlation with immune infiltration in Cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC). | 2 |
| 37594950 | 2023 | MLK4 as an immune marker and its correlation with immune infiltration in Cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC). | 2 |
| 30552384 | 2019 | Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells. | 7 |
| 31071576 | 2019 | Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. | 8 |
| 30552384 | 2019 | Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells. | 7 |
| 31071576 | 2019 | Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. | 8 |
| 28757353 | 2017 | Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells. | 6 |
| 28757353 | 2017 | Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells. | 6 |
| 26859459 | 2016 | Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. | 91 |
| 26859459 | 2016 | Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. | 91 |
| 23319808 | 2013 | Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis. | 11 |
| 23319808 | 2013 | Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis. | 11 |
| 21602844 | 2012 | MLK4 has negative effect on TLR4 signaling. | 18 |
| 21602844 | 2012 | MLK4 has negative effect on TLR4 signaling. | 18 |
Citation
Dessen P
MAP3K21 (mitogen-activated protein kinase kinase kinase 21)
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/gene/56675/map3k21-(mitogen-activated-protein-kinase-kinase-kinase-21)
