DCHS2 (dachsous cadherin-related 2)

2016-12-01  

Identity

HGNC
DCHS2
LOCATION
4q31.3
LOCUSID
54798
ALIAS
CDH27,CDHJ,CDHR7,PCDH23,PCDHJ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54798
MIM: 612486
HGNC: 23111
Ensembl: ENSG00000197410

Variants:

dbSNP: 54798
ClinVar: 54798
TCGA: ENSG00000197410
COSMIC: DCHS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197410ENST00000339452A0A0A0MRC0
ENSG00000197410ENST00000357232A0A096LNH0

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
331081462020Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.7
331081462020Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.7
268769842016Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample.5
268769842016Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample.5
220059312012Genome-wide association analysis of age-at-onset in Alzheimer's disease.55
229602372012Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.5
220059312012Genome-wide association analysis of age-at-onset in Alzheimer's disease.55
229602372012Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.5

Citation

Dessen P

DCHS2 (dachsous cadherin-related 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56683/dchs2-(dachsous-cadherin-related-2)