Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55699
MIM: 612801
HGNC: 29685
Ensembl: ENSG00000067704
Variants:
dbSNP: 55699
ClinVar: 55699
TCGA: ENSG00000067704
COSMIC: IARS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000067704 | ENST00000366922 | Q9NSE4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33327715 | 2021 | Biallelic IARS2 mutations presenting as sideroblastic anemia. | 5 |
| 33327715 | 2021 | Biallelic IARS2 mutations presenting as sideroblastic anemia. | 5 |
| 30832756 | 2019 | Knockdown of IARS2 Inhibited Proliferation of Acute Myeloid Leukemia Cells by Regulating p53/p21/PCNA/eIF4E Pathway. | 5 |
| 30832756 | 2019 | Knockdown of IARS2 Inhibited Proliferation of Acute Myeloid Leukemia Cells by Regulating p53/p21/PCNA/eIF4E Pathway. | 5 |
| 26639235 | 2016 | IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis. | 6 |
| 27078007 | 2016 | Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. | 7 |
| 26639235 | 2016 | IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis. | 6 |
| 27078007 | 2016 | Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy. | 7 |
| 26722399 | 2015 | Expression of IARS2 gene in colon cancer and effect of its knockdown on biological behavior of RKO cells. | 8 |
| 26722399 | 2015 | Expression of IARS2 gene in colon cancer and effect of its knockdown on biological behavior of RKO cells. | 8 |
| 25130867 | 2014 | Mutation in the nuclear-encoded mitochondrial isoleucyl-tRNA synthetase IARS2 in patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome. | 42 |
| 25130867 | 2014 | Mutation in the nuclear-encoded mitochondrial isoleucyl-tRNA synthetase IARS2 in patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome. | 42 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 19209188 | 2009 | Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. | 5 |
Citation
Dessen P
IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2016-12-01
Online version: http://atlasgeneticsoncology.org/gene/56687/iars2-(isoleucyl-trna-synthetase-2-mitochondrial)
