GORASP1 (golgi reassembly stacking protein 1)

2016-12-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
GOLPH5,GRASP65,P65
FUSION GENES

Other Information

Locus ID:

NCBI: 64689
MIM: 606867
HGNC: 16769
Ensembl: ENSG00000114745

Variants:

dbSNP: 64689
ClinVar: 64689
TCGA: ENSG00000114745
COSMIC: GORASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114745ENST00000319283Q9BQQ3
ENSG00000114745ENST00000319283A0A024R2U5
ENSG00000114745ENST00000416741C9J5S6
ENSG00000114745ENST00000419156H7C0J2
ENSG00000114745ENST00000422110B3KPY8
ENSG00000114745ENST00000431601Q9BQQ3
ENSG00000114745ENST00000437458C9J0V5
ENSG00000114745ENST00000441081C9J9V9
ENSG00000114745ENST00000452389Q9BQQ3
ENSG00000114745ENST00000453680G3V0G1
ENSG00000114745ENST00000479927B4E1H8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
353128662022GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.12
353128662022GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.12
333015662021Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.23
333015662021Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.23
323318362020Markers of malignant prostate cancer cells: Golgi localization of α-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface.11
328227312020Biophysical characterization of intrinsically disordered human Golgi matrix protein GRASP65.1
323318362020Markers of malignant prostate cancer cells: Golgi localization of α-mannosidase 1A at GM130-GRASP65 site and appearance of high mannose N-glycans on cell surface.11
328227312020Biophysical characterization of intrinsically disordered human Golgi matrix protein GRASP65.1
305660312019DjA1 maintains Golgi integrity via interaction with GRASP65.8
313360002019GRASP65 controls Golgi position and structure during G2/M transition by regulating the stability of microtubules.6
305660312019DjA1 maintains Golgi integrity via interaction with GRASP65.8
313360002019GRASP65 controls Golgi position and structure during G2/M transition by regulating the stability of microtubules.6
287826252017Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.11
288145012017Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function.56
287826252017Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N-glycans in aggressive prostate cancer cells.11

Citation

Dessen P

GORASP1 (golgi reassembly stacking protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56688/gorasp1-(golgi-reassembly-stacking-protein-1)