UGT2B28 (UDP glucuronosyltransferase family 2 member B28)

2017-01-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 54490
MIM: 606497
HGNC: 13479
Ensembl: ENSG00000135226

Variants:

dbSNP: 54490
ClinVar: 54490
TCGA: ENSG00000135226
COSMIC: UGT2B28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135226ENST00000335568Q9BY64
ENSG00000135226ENST00000511240Q9BY64

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363437862023UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways.3
363479652023Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.2
363437862023UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways.3
363479652023Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.2
359541732022Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients.0
359541732022Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients.0
306286802019Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.10
318059792019Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.4
306286802019Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.10
318059792019Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.4
293571082018rs142362919 and rs7681187 Are cis-Regulatory Variations for Human UGT2B28 in Breast.1
293571082018rs142362919 and rs7681187 Are cis-Regulatory Variations for Human UGT2B28 in Breast.1
288825662017Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.3
288825662017Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.3
262156102016The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.16

Citation

Dessen P

UGT2B28 (UDP glucuronosyltransferase family 2 member B28)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56693/ugt2b28-(udp-glucuronosyltransferase-family-2-member-b28)