RPS7 (ribosomal protein S7)

2017-01-01  

Identity

HGNC
LOCATION
2p25.3
LOCUSID
ALIAS
DBA8,S7,eS7
FUSION GENES

Other Information

Locus ID:

NCBI: 6201
MIM: 603658
HGNC: 10440
Ensembl: ENSG00000171863

Variants:

dbSNP: 6201
ClinVar: 6201
TCGA: ENSG00000171863
COSMIC: RPS7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171863ENST00000403564P62081
ENSG00000171863ENST00000406376P62081
ENSG00000171863ENST00000407445B5MCP9
ENSG00000171863ENST00000462576P62081
ENSG00000171863ENST00000645674P62081
ENSG00000171863ENST00000646909P62081
ENSG00000171863ENST00000647131A0A2R8Y623

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383269082024RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling.1
383269082024RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling.1
360579182023Splice-site variant in the RPS7 5'-UTR leads to a decrease in the mRNA level and development of Diamond-Blackfan anemia.1
360579182023Splice-site variant in the RPS7 5'-UTR leads to a decrease in the mRNA level and development of Diamond-Blackfan anemia.1
358710332022Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress.2
358710332022Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress.2
339352842021SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7.19
339352842021SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7.19
302475452019Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress.9
302475452019Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress.9
285106972017BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.5
285106972017BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.5
267355792016RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis.22
267355792016RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis.22
264429812015Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation.9

Citation

Dessen P

RPS7 (ribosomal protein S7)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56722/rps7-(ribosomal-protein-s7)