CAVIN3 (caveolae associated protein 3)

2017-04-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
HSRBC,PRKCDBP,SRBC,cavin-3

Other Information

Locus ID:

NCBI: 112464
MIM: 618303
HGNC: 9400
Ensembl: ENSG00000170955

Variants:

dbSNP: 112464
ClinVar: 112464
TCGA: ENSG00000170955
COSMIC: CAVIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170955ENST00000303927Q969G5
ENSG00000170955ENST00000530979E9PIE3

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA39ADRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192625642009SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.72
244730722013Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae.39
116918162001Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.32
196795652009The DNA methylome of pediatric acute lymphoblastic leukemia.32
219132172012Down-regulation of the cavin family proteins in breast cancer.21
240695282013Cavin-3 dictates the balance between ERK and Akt signaling.19
255888332015Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.18
219801362011Epigenetic alteration of PRKCDBP in colorectal cancers and its implication in tumor cell resistance to TNFα-induced apoptosis.16
180590342008Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses.15

Citation

Dessen P

CAVIN3 (caveolae associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56723/cavin3-(caveolae-associated-protein-3)