Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
MGC:15815,X11L2,mint3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9546
MIM: 604262
HGNC: 580
Ensembl: ENSG00000011132
Variants:
dbSNP: 9546
ClinVar: 9546
TCGA: ENSG00000011132
COSMIC: APBA3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000011132 | ENST00000316757 | O96018 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Neuronal System | REACTOME | R-HSA-112316 |
| Protein-protein interactions at synapses | REACTOME | R-HSA-6794362 |
| Interactions of neurexins and neuroligins at synapses | REACTOME | R-HSA-6794361 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38081808 | 2023 | Mint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation. | 0 |
| 38081808 | 2023 | Mint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation. | 0 |
| 34655613 | 2021 | Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3. | 6 |
| 34655613 | 2021 | Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3. | 6 |
| 32826949 | 2020 | Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1. | 11 |
| 32826949 | 2020 | Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1. | 11 |
| 26948053 | 2016 | NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. | 21 |
| 26948053 | 2016 | NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. | 21 |
| 24742670 | 2014 | Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation. | 0 |
| 24867948 | 2014 | FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. | 15 |
| 24742670 | 2014 | Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation. | 0 |
| 24867948 | 2014 | FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. | 15 |
| 23965993 | 2013 | Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. | 19 |
| 23965993 | 2013 | Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. | 19 |
| 21178287 | 2011 | Signaling via amyloid precursor-like proteins APLP1 and APLP2. | 16 |
Citation
Dessen P
APBA3 (amyloid beta precursor protein binding family A member 3)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56739/apba3-(amyloid-beta-precursor-protein-binding-family-a-member-3)
