SPO11 (SPO11 initiator of meiotic double stranded breaks)

2017-04-01  

Identity

HGNC
SPO11
LOCATION
20q13.31
LOCUSID
23626
ALIAS
CT35,SPATA43,TOPOVIA,TOPVIA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23626
MIM: 605114
HGNC: 11250
Ensembl: ENSG00000054796

Variants:

dbSNP: 23626
ClinVar: 23626
TCGA: ENSG00000054796
COSMIC: SPO11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054796ENST00000345868Q9Y5K1
ENSG00000054796ENST00000371260Q5TCH7
ENSG00000054796ENST00000371263Q9Y5K1
ENSG00000054796ENST00000418127Q5TCH6
ENSG00000054796ENST00000494972H0YCK9

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446

References

Pubmed IDYearTitleCitations
336587102021Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.12
336587102021Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8.12
280509282017The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis.4
280509282017The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis.4
266630672015[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].3
266630672015[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].3
250051692014Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility.11
250051692014Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility.11
215568912011An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population.12
215568912011An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population.12
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.61
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.61
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
181668242008Genetic investigation of four meiotic genes in women with premature ovarian failure.40

Citation

Dessen P

SPO11 (SPO11 initiator of meiotic double stranded breaks)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56743/spo11-(spo11-initiator-of-meiotic-double-stranded-breaks)