Identity
HGNC
LOCATION
20q13.31
LOCUSID
ALIAS
CT35,SPATA43,TOPOVIA,TOPVIA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23626
MIM: 605114
HGNC: 11250
Ensembl: ENSG00000054796
Variants:
dbSNP: 23626
ClinVar: 23626
TCGA: ENSG00000054796
COSMIC: SPO11
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell Cycle | REACTOME | R-HSA-1640170 |
| Meiosis | REACTOME | R-HSA-1500620 |
| Meiotic recombination | REACTOME | R-HSA-912446 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33658710 | 2021 | Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8. | 12 |
| 33658710 | 2021 | Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8. | 12 |
| 28050928 | 2017 | The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. | 4 |
| 28050928 | 2017 | The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. | 4 |
| 26663067 | 2015 | [Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese]. | 3 |
| 26663067 | 2015 | [Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese]. | 3 |
| 25005169 | 2014 | Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility. | 11 |
| 25005169 | 2014 | Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility. | 11 |
| 21556891 | 2011 | An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population. | 12 |
| 21556891 | 2011 | An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population. | 12 |
| 20378615 | 2010 | Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. | 61 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20378615 | 2010 | Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. | 61 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 18166824 | 2008 | Genetic investigation of four meiotic genes in women with premature ovarian failure. | 40 |
Citation
Dessen P
SPO11 (SPO11 initiator of meiotic double stranded breaks)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56743/spo11-(spo11-initiator-of-meiotic-double-stranded-breaks)
