DEDD (death effector domain containing)

2017-04-01  

Identity

HGNC
DEDD
LOCATION
1q23.3
LOCUSID
9191
ALIAS
CASP8IP1,DEDD1,DEFT,FLDED1,KE05

Other Information

Locus ID:

NCBI: 9191
MIM: 606841
HGNC: 2755
Ensembl: ENSG00000158796

Variants:

dbSNP: 9191
ClinVar: 9191
TCGA: ENSG00000158796
COSMIC: DEDD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158796ENST00000368005B1AQP5
ENSG00000158796ENST00000368006O75618
ENSG00000158796ENST00000458050O75618
ENSG00000158796ENST00000464113V9GY27
ENSG00000158796ENST00000490843O75618
ENSG00000158796ENST00000545495O75618

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
307778792019MCL1 and DEDD Promote Urothelial Carcinoma Progression.3
307778792019MCL1 and DEDD Promote Urothelial Carcinoma Progression.3
299539652018MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer.21
299539652018MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer.21
280009002017miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD.40
280009002017miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD.40
227190722012DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer.94
227190722012DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer.94
200701222010Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death.1
200701222010Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death.1
125278982003DEDD and DEDD2 associate with caspase-8/10 and signal cell death.27
125278982003DEDD and DEDD2 associate with caspase-8/10 and signal cell death.27
119654972002Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.10
119654972002Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.10

Citation

Dessen P

DEDD (death effector domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56750/dedd-(death-effector-domain-containing)