HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
2017-04-01 AffiliationIdentity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
BCNG-2,BCNG2,HAC-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 610
MIM: 602781
HGNC: 4846
Ensembl: ENSG00000099822
Variants:
dbSNP: 610
ClinVar: 610
TCGA: ENSG00000099822
COSMIC: HCN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000099822 | ENST00000251287 | Q9UL51 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35662339 | 2022 | HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling. | 5 |
| 35662339 | 2022 | HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling. | 5 |
| 31916853 | 2020 | HCN2 and TBX3 Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells. | 5 |
| 32543742 | 2020 | Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). | 10 |
| 31916853 | 2020 | HCN2 and TBX3 Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells. | 5 |
| 32543742 | 2020 | Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). | 10 |
| 31682955 | 2019 | Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study. | 2 |
| 31682955 | 2019 | Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study. | 2 |
| 29047147 | 2018 | Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies. | 4 |
| 29064616 | 2018 | Gain-of-function HCN2 variants in genetic epilepsy. | 8 |
| 29047147 | 2018 | Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies. | 4 |
| 29064616 | 2018 | Gain-of-function HCN2 variants in genetic epilepsy. | 8 |
| 28017718 | 2017 | Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2). | 4 |
| 28864772 | 2017 | Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. | 20 |
| 29054409 | 2017 | Dual expression of constitutively active Gα(s)-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment. | 1 |
Citation
Dessen P
HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56751/hcn2-(hyperpolarization-activated-cyclic-nucleotide-gated-potassium-and-sodium-channel-2)
