ALKAL2 (ALK and LTK ligand 2)

2017-04-01  

Identity

HGNC
ALKAL2
LOCATION
2p25.3
LOCUSID
285016
ALIAS
AUGA,FAM150B,PRO1097,RGPG542

Other Information

Locus ID:

NCBI: 285016
HGNC: 27683
Ensembl: ENSG00000189292

Variants:

dbSNP: 285016
ClinVar: 285016
TCGA: ENSG00000189292
COSMIC: ALKAL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189292ENST00000344414B5MC33
ENSG00000189292ENST00000401489H0Y3U4
ENSG00000189292ENST00000401503B5MCG6
ENSG00000189292ENST00000403610Q6UX46
ENSG00000189292ENST00000405290B5MC33
ENSG00000189292ENST00000452023A0A0B4J1W8
ENSG00000189292ENST00000619265Q6UX46

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
353511522022The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer.6
353511522022The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer.6
334113312021ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.29
334113312021ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.29
293175322018ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.42
293175322018ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.42
264187452015FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.80
266300102015Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.0
264187452015FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.80
266300102015Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.0
253318932014Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.30
253318932014Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.30

Citation

Dessen P

ALKAL2 (ALK and LTK ligand 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56753/humanGenome