Identity
HGNC
LOCATION
10q21.2
LOCUSID
ALIAS
PLEKHK1,bA531F24.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 219790
MIM: 618450
HGNC: 19364
Ensembl: ENSG00000182010
Variants:
dbSNP: 219790
ClinVar: 219790
TCGA: ENSG00000182010
COSMIC: RTKN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182010 | ENST00000315289 | Q5SVY4 |
| ENSG00000182010 | ENST00000373789 | Q8IZC4 |
| ENSG00000182010 | ENST00000395260 | Q8IZC4 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36952123 | 2023 | RTKN2 Inhibits the Growth, Migration, Invasion and Glycolysis of Lung Adenocarcinoma Cells by Inactivating the NF-κB Signalling Pathway. | 1 |
| 38155217 | 2023 | RTKN2 knockdown alleviates the malignancy of breast cancer cells by regulating the Wnt/β-catenin pathway. | 1 |
| 36952123 | 2023 | RTKN2 Inhibits the Growth, Migration, Invasion and Glycolysis of Lung Adenocarcinoma Cells by Inactivating the NF-κB Signalling Pathway. | 1 |
| 38155217 | 2023 | RTKN2 knockdown alleviates the malignancy of breast cancer cells by regulating the Wnt/β-catenin pathway. | 1 |
| 33311442 | 2020 | CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. | 139 |
| 33311442 | 2020 | CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. | 139 |
| 30309296 | 2019 | MicroRNA-181 Functions as an Antioncogene and Mediates NF-κB Pathway by Targeting RTKN2 in Ovarian Cancers. | 12 |
| 30309296 | 2019 | MicroRNA-181 Functions as an Antioncogene and Mediates NF-κB Pathway by Targeting RTKN2 in Ovarian Cancers. | 12 |
| 29886034 | 2018 | Rare genetic mutations in Pakistani patients with dilated cardiomyopathy. | 12 |
| 30389712 | 2018 | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells. | 3 |
| 29886034 | 2018 | Rare genetic mutations in Pakistani patients with dilated cardiomyopathy. | 12 |
| 30389712 | 2018 | Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells. | 3 |
| 27081789 | 2016 | Knockdown of Rhotekin 2 expression suppresses proliferation and invasion and induces apoptosis in hepatocellular carcinoma cells. | 8 |
| 27081789 | 2016 | Knockdown of Rhotekin 2 expression suppresses proliferation and invasion and induces apoptosis in hepatocellular carcinoma cells. | 8 |
| 24880483 | 2014 | miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells. | 15 |
Citation
Dessen P
RTKN2 (rhotekin 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56760/rtkn2-(rhotekin-2)
