Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84888
MIM: 608238
HGNC: 30227
Ensembl: ENSG00000138600
Variants:
dbSNP: 84888
ClinVar: 84888
TCGA: ENSG00000138600
COSMIC: SPPL2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138600 | ENST00000261854 | Q8TCT8 |
| ENSG00000138600 | ENST00000558414 | H0YNA7 |
| ENSG00000138600 | ENST00000558934 | H0YNA2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Death Receptor Signalling | REACTOME | R-HSA-73887 |
| TNF signaling | REACTOME | R-HSA-75893 |
| Regulation of TNFR1 signaling | REACTOME | R-HSA-5357905 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30819724 | 2019 | Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. | 17 |
| 30819724 | 2019 | Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. | 17 |
| 30127434 | 2018 | Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. | 56 |
| 30127434 | 2018 | Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. | 56 |
| 26987812 | 2016 | Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. | 12 |
| 26987812 | 2016 | Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. | 12 |
| 24872421 | 2014 | Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). | 18 |
| 25035924 | 2014 | Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. | 10 |
| 24872421 | 2014 | Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). | 18 |
| 25035924 | 2014 | Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. | 10 |
| 21896273 | 2011 | Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. | 16 |
| 21896273 | 2011 | Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. | 16 |
| 17965014 | 2008 | Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. | 76 |
| 17965014 | 2008 | Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. | 76 |
| 17557115 | 2007 | The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. | 56 |
Citation
Dessen P
SPPL2A (signal peptide peptidase like 2A)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56771/sppl2a-(signal-peptide-peptidase-like-2a)
