NUDT21 (nudix hydrolase 21)

2017-04-01  

Identity

HGNC
LOCATION
16q13
LOCUSID
ALIAS
CFIM25,CPSF5
FUSION GENES

Other Information

Locus ID:

NCBI: 11051
MIM: 604978
HGNC: 13870
Ensembl: ENSG00000167005

Variants:

dbSNP: 11051
ClinVar: 11051
TCGA: ENSG00000167005
COSMIC: NUDT21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167005ENST00000300291O43809
ENSG00000167005ENST00000300291A0A024R6W2
ENSG00000167005ENST00000566340H3BND3
ENSG00000167005ENST00000568822H3BV41

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381959522024NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis.0
383225932024Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis.0
383498662024Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma.0
381959522024NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis.0
383225932024Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis.0
383498662024Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma.0
359651012023The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease.4
373897562023NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.1
374147872023Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection.3
374221932023PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation.1
374980642023A new pathway for the transformation of AML in MDS: APA mechanism regulated by NUDT21 and RUNX1.0
377372602023Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis.1
379999792023LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.0
359651012023The emerging roles of CFIm25 (NUDT21/CPSF5) in human biology and disease.4
373897562023NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.1

Citation

Dessen P

NUDT21 (nudix hydrolase 21)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56782/nudt21-(nudix-hydrolase-21)