WASHC1 (WASH complex subunit 1)

2017-04-01  

Identity

HGNC
LOCATION
9p24.3
LOCUSID
ALIAS
FAM39E,WASH,WASH1

Other Information

Locus ID:

NCBI: 100287171
MIM: 613632
HGNC: 24361
Ensembl: ENSG00000181404

Variants:

dbSNP: 100287171
ClinVar: 100287171
TCGA: ENSG00000181404
COSMIC: WASHC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181404ENST00000442898A8K0Z3
ENSG00000181404ENST00000642633A0A2R8YDD3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
357330632022WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.0
357330632022WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.0
298917222018HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.30
298917222018HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.30
279092462017Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.35
285512752017Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients.6
285899392017WASH maintains NKp46(+) ILC3 cells by promoting AHR expression.7
279092462017Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.35
285512752017Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients.6
285899392017WASH maintains NKp46(+) ILC3 cells by promoting AHR expression.7
274416532016WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.15
274416532016WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.15
254311352015Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.18
260412862015Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.18
260660812015WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway.46

Citation

Dessen P

WASHC1 (WASH complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56793/washc1-(wash-complex-subunit-1)