MX2 (MX dynamin like GTPase 2)

2017-04-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
MXB
FUSION GENES

Other Information

Locus ID:

NCBI: 4600
MIM: 147890
HGNC: 7533
Ensembl: ENSG00000183486

Variants:

dbSNP: 4600
ClinVar: 4600
TCGA: ENSG00000183486
COSMIC: MX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183486ENST00000330714P20592
ENSG00000183486ENST00000416447C9J9T4
ENSG00000183486ENST00000418103C9JEL4
ENSG00000183486ENST00000435611C9JS04
ENSG00000183486ENST00000436410C9JZQ9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240484772013Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.223
241214412013MX2 is an interferon-induced inhibitor of HIV-1 infection.189
240556052013The interferon-inducible MxB protein inhibits HIV-1 infection.136
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
247608932014Host and viral determinants of Mx2 antiretroviral activity.70
251230632014MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1.66
253481552014Host and viral determinants for MxB restriction of HIV-1 infection.42
248991772014Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.34
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

MX2 (MX dynamin like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56797/mx2-(mx-dynamin-like-gtpase-2)