UFD1 (ubiquitin recognition factor in ER associated degradation 1)

2017-04-01  

Identity

HGNC
UFD1
LOCATION
22q11.21
LOCUSID
7353
ALIAS
UFD1L

Other Information

Locus ID:

NCBI: 7353
MIM: 601754
HGNC: 12520
Ensembl: ENSG00000070010

Variants:

dbSNP: 7353
ClinVar: 7353
TCGA: ENSG00000070010
COSMIC: UFD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070010ENST00000263202Q92890
ENSG00000070010ENST00000263202Q541A5
ENSG00000070010ENST00000399523Q92890
ENSG00000070010ENST00000421968C9IZG3
ENSG00000070010ENST00000447868C9JNP9
ENSG00000070010ENST00000474226C9J7C8
ENSG00000070010ENST00000494054C9J6N9

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
p97-Ufd1-Npl4 complexKEGGhsa_M00400
HRD1/SEL1 ERAD complexKEGGhsa_M00403
HRD1/SEL1 ERAD complexKEGGM00403
p97-Ufd1-Npl4 complexKEGGM00400
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion Synthesis by POLHREACTOMER-HSA-110320
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359206412022Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.11
360875752022Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1.2
359206412022Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.11
360875752022Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1.2
330370852021PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.8
334026762021Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.35
330370852021PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.8
334026762021Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.35
322893422020Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.4
322893422020Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.4
314776232019Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP.1
316239622019Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.40
314776232019Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP.1
316239622019Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.40
297437252018UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.18

Citation

Dessen P

UFD1 (ubiquitin recognition factor in ER associated degradation 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56823/ufd1-(ubiquitin-recognition-factor-in-er-associated-degradation-1)