PYCR2 (pyrroline-5-carboxylate reductase 2)

2017-04-01  

Identity

HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
HLD10,P5CR2
FUSION GENES

Other Information

Locus ID:

NCBI: 29920
MIM: 616406
HGNC: 30262
Ensembl: ENSG00000143811

Variants:

dbSNP: 29920
ClinVar: 29920
TCGA: ENSG00000143811
COSMIC: PYCR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143811ENST00000343818Q96C36
ENSG00000143811ENST00000343818A0A0S2Z5U6
ENSG00000143811ENST00000472798A0A087WX69
ENSG00000143811ENST00000489681A0A087WZF0
ENSG00000143811ENST00000612039A0A087WTV6
ENSG00000143811ENST00000612651A0A087WZR9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Proline biosynthesis, glutamate => prolineKEGGhsa_M00015
Proline biosynthesis, glutamate => prolineKEGGM00015
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371417412023Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood.0
373295342023LncRNA MALAT1 regulates growth of carcinoma of the lung through modulating miR-338-3p/PYCR2 axis.0
375085472023Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.0
377085982023PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway.2
371417412023Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood.0
373295342023LncRNA MALAT1 regulates growth of carcinoma of the lung through modulating miR-338-3p/PYCR2 axis.0
375085472023Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.0
377085982023PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway.2
337715082021Disease variants of human Δ(1)-pyrroline-5-carboxylate reductase 2 (PYCR2).7
340373072021Expanding the genotypic spectrum of PYCR2 and a common ancestry in Thai patients with hypomyelinating leukodystrophy 10.2
343323252021The upregulation of PYCR2 is associated with aggressive colon cancer progression and a poor prognosis.9
345128172021Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway.10
337715082021Disease variants of human Δ(1)-pyrroline-5-carboxylate reductase 2 (PYCR2).7
340373072021Expanding the genotypic spectrum of PYCR2 and a common ancestry in Thai patients with hypomyelinating leukodystrophy 10.2
343323252021The upregulation of PYCR2 is associated with aggressive colon cancer progression and a poor prognosis.9

Citation

Dessen P

PYCR2 (pyrroline-5-carboxylate reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56827/pycr2-(pyrroline-5-carboxylate-reductase-2)