DRD5 (dopamine receptor D5)

2017-04-01  

Identity

HGNC
LOCATION
4p16.1
LOCUSID
ALIAS
DBDR,DRD1B,DRD1L2

Other Information

Locus ID:

NCBI: 1816
MIM: 126453
HGNC: 3026
Ensembl: ENSG00000169676

Variants:

dbSNP: 1816
ClinVar: 1816
TCGA: ENSG00000169676
COSMIC: DRD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169676ENST00000304374P21918

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359619472023Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.0
359619472023Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.0
321835362020The effects of dopamine receptor genes on the trajectories of sport participation from adolescence through young adulthood.7
329073772020Hypermethylation of DRD5 Promoter Is a Biomarker Across 12 Cancer Types.1
321835362020The effects of dopamine receptor genes on the trajectories of sport participation from adolescence through young adulthood.7
329073772020Hypermethylation of DRD5 Promoter Is a Biomarker Across 12 Cancer Types.1
305591682019Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.34
309576272019Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD (5) R (F173L) Transgenic Mice.10
305591682019Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.34
309576272019Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD (5) R (F173L) Transgenic Mice.10
284519352018Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.10
301536502018Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation.13
284519352018Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.10
301536502018Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation.13
286139752017Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death.45

Citation

Dessen P

DRD5 (dopamine receptor D5)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56835/drd5-(dopamine-receptor-d5)