DRD5 (dopamine receptor D5)

2017-04-01  

Identity

HGNC
LOCATION
4p16.1
LOCUSID
ALIAS
DBDR,DRD1B,DRD1L2

Other Information

Locus ID:

NCBI: 1816
MIM: 126453
HGNC: 3026
Ensembl: ENSG00000169676

Variants:

dbSNP: 1816
ClinVar: 1816
TCGA: ENSG00000169676
COSMIC: DRD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169676ENST00000304374P21918

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
167749752006Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).139
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
157172912005Support for association between ADHD and two candidate genes: NET1 and DRD1.53
163528632006D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure.52
184649322008Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.51
205319392010DISC1 regulates primary cilia that display specific dopamine receptors.51
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
191716712009Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.38
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38

Citation

Dessen P

DRD5 (dopamine receptor D5)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56835/drd5-(dopamine-receptor-d5)