ALKAL1 (ALK and LTK ligand 1)

2017-04-01 Affiliation

Identity

HGNC

ALKAL1

LOCATION

8q11.23

LOCUSID

389658

ALIAS

AUGA,AUGB,FAM150A,UNQ9433

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 389658
HGNC: 33775
Ensembl: ENSG00000196711

Variants:

dbSNP: 389658
ClinVar: 389658
TCGA: ENSG00000196711
COSMIC: ALKAL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196711	ENST00000358543	Q6UXT8
ENSG00000196711	ENST00000523939	Q6UXT8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26418745	2015	FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.	40
26630010	2015	Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.	39
25331893	2014	Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.	18
29317532	2018	ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.	15

Citation

Dessen P

ALKAL1 (ALK and LTK ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56836/alkal1-(alk-and-ltk-ligand-1)