Identity
HGNC
LOCATION
4q32.1
LOCUSID
ALIAS
HYPTRP,TDO,TO,TPH2,TRPO
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6999
MIM: 191070
HGNC: 11708
Ensembl: ENSG00000151790
Variants:
dbSNP: 6999
ClinVar: 6999
TCGA: ENSG00000151790
COSMIC: TDO2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000151790 | ENST00000506072 | D6RA50 |
| ENSG00000151790 | ENST00000507590 | D6RB68 |
| ENSG00000151790 | ENST00000536354 | P48775 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35679834 | 2023 | Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells. | 2 |
| 35679834 | 2023 | Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells. | 2 |
| 34714577 | 2022 | Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. | 23 |
| 34969166 | 2022 | Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis. | 3 |
| 35056756 | 2022 | MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma. | 5 |
| 35733134 | 2022 | High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis. | 3 |
| 35970080 | 2022 | Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta. | 0 |
| 34714577 | 2022 | Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. | 23 |
| 34969166 | 2022 | Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis. | 3 |
| 35056756 | 2022 | MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma. | 5 |
| 35733134 | 2022 | High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis. | 3 |
| 35970080 | 2022 | Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta. | 0 |
| 33846800 | 2021 | Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells. | 7 |
| 34051337 | 2021 | TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway. | 13 |
| 34101386 | 2021 | TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer. | 7 |
Citation
Dessen P
TDO2 (tryptophan 2,3-dioxygenase)
Atlas Genet Cytogenet Oncol Haematol. 2017-04-01
Online version: http://atlasgeneticsoncology.org/gene/56848/tdo2-(tryptophan-2-3-dioxygenase)
