UCK1 (uridine-cytidine kinase 1)

2017-04-01  

Identity

HGNC
UCK1
LOCATION
9q34.13
LOCUSID
83549
ALIAS
URK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83549
MIM: 609328
HGNC: 14859
Ensembl: ENSG00000130717

Variants:

dbSNP: 83549
ClinVar: 83549
TCGA: ENSG00000130717
COSMIC: UCK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130717ENST00000372208Q9HA47
ENSG00000130717ENST00000372208A0A024R8E7
ENSG00000130717ENST00000372210Q9HA47
ENSG00000130717ENST00000372211Q9HA47
ENSG00000130717ENST00000372215Q9HA47
ENSG00000130717ENST00000491309G3V170

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
272397012016The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma.14
279066292016Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.5
272397012016The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma.14
279066292016Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.5
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.25
180802172008Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins.2
180802172008Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins.2

Citation

Dessen P

UCK1 (uridine-cytidine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56856/uck1-(uridine-cytidine-kinase-1)