CREBRF (CREB3 regulatory factor)

2017-05-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
C5orf41,LRF
FUSION GENES

Other Information

Locus ID:

NCBI: 153222
MIM: 617109
HGNC: 24050
Ensembl: ENSG00000164463

Variants:

dbSNP: 153222
ClinVar: 153222
TCGA: ENSG00000164463
COSMIC: CREBRF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164463ENST00000296953Q8IUR6
ENSG00000164463ENST00000520420Q8IUR6
ENSG00000164463ENST00000522692Q8IUR6
ENSG00000164463ENST00000523161E5RI19

Expression (GTEx)

0
5
10
15
20
25

References

Pubmed IDYearTitleCitations
274553492016A thrifty variant in CREBRF strongly influences body mass index in Samoans.38
272787372016CREBRF is a potent tumor suppressor of glioblastoma by blocking hypoxia-induced autophagy via the CREB3/ATG5 pathway.10
284050132017A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.9
297216342018Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.9
289284632018Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood.8
297296922018CREBRF promotes the proliferation of human gastric cancer cells via the AKT signaling pathway.6
298771582018Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations.3
312803402019Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.2
299584632018Exploring the Roles of CREBRF and TRIM2 in the Regulation of Angiogenesis by High-Density Lipoproteins.1

Citation

Dessen P

CREBRF (CREB3 regulatory factor)

Atlas Genet Cytogenet Oncol Haematol. 2017-05-01

Online version: http://atlasgeneticsoncology.org/gene/56901/crebrf-(creb3-regulatory-factor)