ABRAXAS2 (abraxas 2, BRISC complex subunit)

2017-05-01  

Identity

HGNC
ABRAXAS2
LOCATION
10q26.13
LOCUSID
23172
ALIAS
ABRO1,FAM175B,KIAA0157

Other Information

Locus ID:

NCBI: 23172
MIM: 611144
HGNC: 28975
Ensembl: ENSG00000165660

Variants:

dbSNP: 23172
ClinVar: 23172
TCGA: ENSG00000165660
COSMIC: ABRAXAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165660ENST00000298492Q15018

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
328451622021Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1.0
331070212021ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.6
328451622021Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1.0
331070212021ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.6
307554202019The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.15
308547842019FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma.6
307554202019The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.15
308547842019FAM175B promotes apoptosis by inhibiting ATF4 ubiquitination in esophageal squamous cell carcinoma.6
279939342017Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution.18
279939342017Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution.18
263440972015Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.30
263440972015Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.30
252831482014ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.30
252831482014ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.30
211950822011Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.17

Citation

Dessen P

ABRAXAS2 (abraxas 2, BRISC complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2017-05-01

Online version: http://atlasgeneticsoncology.org/gene/56904/abraxas2-(abraxas-2-brisc-complex-subunit)