Identity
HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
AGM5,HsLRRC8A,LRRC8,SWELL1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 56262
MIM: 608360
HGNC: 19027
Ensembl: ENSG00000136802
Variants:
dbSNP: 56262
ClinVar: 56262
TCGA: ENSG00000136802
COSMIC: LRRC8A
RNA/Proteins
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37468723 | 2024 | Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206. | 0 |
| 37524750 | 2024 | Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward. | 0 |
| 38350542 | 2024 | LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway. | 2 |
| 37468723 | 2024 | Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206. | 0 |
| 37524750 | 2024 | Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward. | 0 |
| 38350542 | 2024 | LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway. | 2 |
| 37129855 | 2023 | LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells. | 3 |
| 37543949 | 2023 | Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels. | 3 |
| 37129855 | 2023 | LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells. | 3 |
| 37543949 | 2023 | Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels. | 3 |
| 35145074 | 2022 | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. | 9 |
| 35145074 | 2022 | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. | 9 |
| 33356947 | 2021 | LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology. | 13 |
| 33476655 | 2021 | Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells. | 5 |
| 33864161 | 2021 | LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway. | 10 |
Citation
Dessen P
LRRC8A (leucine rich repeat containing 8 VRAC subunit A)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/56915/lrrc8a-(leucine-rich-repeat-containing-8-vrac-subunit-a)
