SRM (spermidine synthase)

2017-08-01  

Identity

HGNC
SRM
LOCATION
1p36.22
LOCUSID
6723
ALIAS
PAPT,SPDSY,SPS1,SRML1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6723
MIM: 182891
HGNC: 11296
Ensembl: ENSG00000116649

Variants:

dbSNP: 6723
ClinVar: 6723
TCGA: ENSG00000116649
COSMIC: SRM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116649ENST00000376957P19623
ENSG00000116649ENST00000459997K7EKM4
ENSG00000116649ENST00000465788K7EQ47
ENSG00000116649ENST00000487300K7ESL0
ENSG00000116649ENST00000490101K7EL89

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
beta-Alanine metabolismKEGGko00410
Glutathione metabolismKEGGko00480
Arginine and proline metabolismKEGGhsa00330
beta-Alanine metabolismKEGGhsa00410
Glutathione metabolismKEGGhsa00480
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348439062022The potential role of c-MYC and polyamine metabolism in multiple drug resistance in bladder cancer investigated by metabonomics.10
348439062022The potential role of c-MYC and polyamine metabolism in multiple drug resistance in bladder cancer investigated by metabonomics.10
175857812007Structure and mechanism of spermidine synthases.46
175857812007Structure and mechanism of spermidine synthases.46

Citation

Dessen P

SRM (spermidine synthase)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56929/srm-(spermidine-synthase)