ATG13 (autophagy related 13)

2017-08-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
KIAA0652,PARATARG8
FUSION GENES

Other Information

Locus ID:

NCBI: 9776
MIM: 615088
HGNC: 29091
Ensembl: ENSG00000175224

Variants:

dbSNP: 9776
ClinVar: 9776
TCGA: ENSG00000175224
COSMIC: ATG13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175224ENST00000359513O75143
ENSG00000175224ENST00000395549J9JIF6
ENSG00000175224ENST00000524625O75143
ENSG00000175224ENST00000525009H0YEM7
ENSG00000175224ENST00000526508O75143
ENSG00000175224ENST00000528494O75143
ENSG00000175224ENST00000529395H0YCL5
ENSG00000175224ENST00000529655O75143
ENSG00000175224ENST00000530500O75143
ENSG00000175224ENST00000531933H0YDR0
ENSG00000175224ENST00000532067H0YF43
ENSG00000175224ENST00000533325E9PPR2
ENSG00000175224ENST00000577256J3KRU6
ENSG00000175224ENST00000578626J3KST9
ENSG00000175224ENST00000580238A0A1B0GXJ3
ENSG00000175224ENST00000581416J3QRL1
ENSG00000175224ENST00000581438J3QLH7
ENSG00000175224ENST00000582547J3QR83
ENSG00000175224ENST00000583249J3QR16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

References

Pubmed IDYearTitleCitations
192251512009ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.679
192118352009Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.642
192583182009ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.479
189361572009Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.178
189361572009Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.178
195973352009Atg101, a novel mammalian autophagy protein interacting with Atg13.157
192872112009A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.146
196903282009mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.88
214753062011Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.63
242901412014Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.42

Citation

Dessen P

ATG13 (autophagy related 13)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56942/atg13-(autophagy-related-13)