CLDN19 (claudin 19)

2017-08-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
HOMG5

Other Information

Locus ID:

NCBI: 149461
MIM: 610036
HGNC: 2040
Ensembl: ENSG00000164007

Variants:

dbSNP: 149461
ClinVar: 149461
TCGA: ENSG00000164007
COSMIC: CLDN19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164007ENST00000296387Q8N6F1
ENSG00000164007ENST00000372539Q8N6F1
ENSG00000164007ENST00000539749Q8N6F1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

References

Pubmed IDYearTitleCitations
335913572021Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1.2
339296922021Heterogeneity is a common ground in familial hypomagnesemia with hypercalciuria and nephrocalcinosis caused by CLDN19 gene mutations.1
335913572021Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1.2
339296922021Heterogeneity is a common ground in familial hypomagnesemia with hypercalciuria and nephrocalcinosis caused by CLDN19 gene mutations.1
305768092019Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis.5
309373962019Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function.9
305768092019Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis.5
309373962019Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function.9
300674192018Familial non-syndromic macular pseudocoloboma secondary to homozygous CLDN19 mutation.3
302321342018Claudin-14 Gene Polymorphisms and Urine Calcium Excretion.7
300674192018Familial non-syndromic macular pseudocoloboma secondary to homozygous CLDN19 mutation.3
302321342018Claudin-14 Gene Polymorphisms and Urine Calcium Excretion.7
275939152016Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression.12
275939152016Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression.12
254106742015Haplotype analysis of CLDN19 single nucleotide polymorphisms in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.5

Citation

Dessen P

CLDN19 (claudin 19)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56945/cldn19-(claudin-19)