EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3)

2017-08-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
C1orf22
FUSION GENES

Other Information

Locus ID:

NCBI: 80267
MIM: 610214
HGNC: 16787
Ensembl: ENSG00000116406

Variants:

dbSNP: 80267
ClinVar: 80267
TCGA: ENSG00000116406
COSMIC: EDEM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116406ENST00000318130Q9BZQ6
ENSG00000116406ENST00000318130A0A024R931
ENSG00000116406ENST00000367512Q9BZQ6
ENSG00000116406ENST00000439962H0Y498

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
Calnexin/calreticulin cycleREACTOMER-HSA-901042
ER Quality Control Compartment (ERQC)REACTOMER-HSA-901032

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358977612022Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer.4
358977612022Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer.4
336716322021EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning.6
341439522021Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation.8
346986342021Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD.7
336716322021EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning.6
341439522021Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation.8
346986342021Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD.7
304967322019IL8 and EDEM3 gene expression ratio indicates peripheral blood mononuclear cell (PBMC) quality.1
304967322019IL8 and EDEM3 gene expression ratio indicates peripheral blood mononuclear cell (PBMC) quality.1
297848792018ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3).18
297848792018ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3).18
283666322017Inhibition of N-glycan processing modulates the network of EDEM3 interactors.5
283666322017Inhibition of N-glycan processing modulates the network of EDEM3 interactors.5

Citation

Dessen P

EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56964/edem3-(er-degradation-enhancing-alpha-mannosidase-like-protein-3)