EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3)

2017-08-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
C1orf22
FUSION GENES

Other Information

Locus ID:

NCBI: 80267
MIM: 610214
HGNC: 16787
Ensembl: ENSG00000116406

Variants:

dbSNP: 80267
ClinVar: 80267
TCGA: ENSG00000116406
COSMIC: EDEM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116406ENST00000318130Q9BZQ6
ENSG00000116406ENST00000318130A0A024R931
ENSG00000116406ENST00000367512Q9BZQ6
ENSG00000116406ENST00000439962H0Y498

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668
Calnexin/calreticulin cycleREACTOMER-HSA-901042
ER Quality Control Compartment (ERQC)REACTOMER-HSA-901032

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
297848792018ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing α-mannosidase-like protein 3 (EDEM3).5
283666322017Inhibition of N-glycan processing modulates the network of EDEM3 interactors.1
304967322019IL8 and EDEM3 gene expression ratio indicates peripheral blood mononuclear cell (PBMC) quality.0

Citation

Dessen P

EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56964/edem3-(er-degradation-enhancing-alpha-mannosidase-like-protein-3)