GRIK3 (glutamate ionotropic receptor kainate type subunit 3)

2017-08-01 Affiliation

Identity

HGNC

GRIK3

LOCATION

1p34.3

LOCUSID

2899

ALIAS

EAA5,GLR7,GLUR7,GluK3,GluR7a

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2899
MIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873

Variants:

dbSNP: 2899
ClinVar: 2899
TCGA: ENSG00000163873
COSMIC: GRIK3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163873	ENST00000373091	Q13003
ENSG00000163873	ENST00000373093	Q13003

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of Kainate Receptors upon glutamate binding	REACTOME	R-HSA-451326
Ionotropic activity of Kainate Receptors	REACTOME	R-HSA-451306
Activation of Ca-permeable Kainate Receptor	REACTOME	R-HSA-451308
Presynaptic function of Kainate receptors	REACTOME	R-HSA-500657

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443937	Drug Toxicity	Disease	VariantAnnotation	associated	PD	27272046
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	27272046
PA452233	antipsychotics	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	27272046

References

Pubmed ID	Year	Title	Citations
34127015	2021	CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205.	8
34127015	2021	CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205.	8
30977227	2019	Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling.	12
30977227	2019	Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling.	12
28005267	2017	Human gingiva transcriptome during wound healing.	14
28631555	2017	GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.	13
28005267	2017	Human gingiva transcriptome during wound healing.	14
28631555	2017	GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC.	13
24449200	2014	1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.	23
24449200	2014	1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.	23
23006490	2013	Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.	3
23006490	2013	Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.	3
20859245	2011	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	5
22232963	2011	[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].	8
20859245	2011	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	5

Citation

Dessen P

GRIK3 (glutamate ionotropic receptor kainate type subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56991/grik3-(glutamate-ionotropic-receptor-kainate-type-subunit-3)