Identity
HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
EAA5,GLR7,GLUR7,GluK3,GluR7a
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2899
MIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873
Variants:
dbSNP: 2899
ClinVar: 2899
TCGA: ENSG00000163873
COSMIC: GRIK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163873 | ENST00000373091 | Q13003 |
| ENSG00000163873 | ENST00000373093 | Q13003 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | associated | PD | 27272046 | |
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 27272046 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 27272046 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34127015 | 2021 | CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205. | 8 |
| 34127015 | 2021 | CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205. | 8 |
| 30977227 | 2019 | Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling. | 12 |
| 30977227 | 2019 | Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling. | 12 |
| 28005267 | 2017 | Human gingiva transcriptome during wound healing. | 14 |
| 28631555 | 2017 | GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC. | 13 |
| 28005267 | 2017 | Human gingiva transcriptome during wound healing. | 14 |
| 28631555 | 2017 | GRIK3: A novel oncogenic protein related to tumor TNM stage, lymph node metastasis, and poor prognosis of GC. | 13 |
| 24449200 | 2014 | 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay. | 23 |
| 24449200 | 2014 | 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay. | 23 |
| 23006490 | 2013 | Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence. | 3 |
| 23006490 | 2013 | Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence. | 3 |
| 20859245 | 2011 | Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol. | 5 |
| 22232963 | 2011 | [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]. | 8 |
| 20859245 | 2011 | Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol. | 5 |
Citation
Dessen P
GRIK3 (glutamate ionotropic receptor kainate type subunit 3)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/56991/grik3-(glutamate-ionotropic-receptor-kainate-type-subunit-3)
