Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3157
MIM: 142940
HGNC: 5007
Ensembl: ENSG00000112972
Variants:
dbSNP: 3157
ClinVar: 3157
TCGA: ENSG00000112972
COSMIC: HMGCS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38308184 | 2024 | CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. | 5 |
| 38608446 | 2024 | Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis. | 0 |
| 38308184 | 2024 | CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. | 5 |
| 38608446 | 2024 | Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis. | 0 |
| 36328117 | 2023 | Compartmentalized activities of HMGCS1 control cervical cancer radiosensitivity. | 3 |
| 36702290 | 2023 | P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression. | 4 |
| 36734275 | 2023 | VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. | 3 |
| 36328117 | 2023 | Compartmentalized activities of HMGCS1 control cervical cancer radiosensitivity. | 3 |
| 36702290 | 2023 | P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression. | 4 |
| 36734275 | 2023 | VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization. | 3 |
| 34454908 | 2022 | Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes. | 1 |
| 34549901 | 2022 | Pan-cancer analysis reveals the oncogenic role of 3-hydroxy-3-methylglutaryl-CoA synthase 1. | 9 |
| 36356901 | 2022 | Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1. | 2 |
| 34454908 | 2022 | Interaction of Gal-7 with HMGCS1 In Vitro May Facilitate Cholesterol Deposition in Cultured Keratinocytes. | 1 |
| 34549901 | 2022 | Pan-cancer analysis reveals the oncogenic role of 3-hydroxy-3-methylglutaryl-CoA synthase 1. | 9 |
Citation
Dessen P
HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/56992/hmgcs1-(3-hydroxy-3-methylglutaryl-coa-synthase-1)
