ACY1 (aminoacylase 1)

2003-06-01  

Identity

HGNC
ACY1
LOCATION
3p21.2
LOCUSID
95
ALIAS
ACY-1,ACY1D,HEL-S-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 95
MIM: 104620
HGNC: 177
Ensembl: ENSG00000243989

Variants:

dbSNP: 95
ClinVar: 95
TCGA: ENSG00000243989
COSMIC: ACY1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243989ENST00000404366Q03154
ENSG00000243989ENST00000404366V9HWA0
ENSG00000243989ENST00000469863C9JYZ0
ENSG00000243989ENST00000476351Q03154
ENSG00000243989ENST00000476854Q03154
ENSG00000243989ENST00000491318F8WC59
ENSG00000243989ENST00000494103Q03154
ENSG00000243989ENST00000635797A0A1B0GU86
ENSG00000243989ENST00000635941A0A1B0GUZ4
ENSG00000243989ENST00000636358Q03154
ENSG00000243989ENST00000636358V9HWA0
ENSG00000243989ENST00000636556A0A1B0GVG0
ENSG00000243989ENST00000636880A0A1B0GU36
ENSG00000243989ENST00000637149A0A1B0GVF7
ENSG00000243989ENST00000637209A0A1B0GVZ3
ENSG00000243989ENST00000637349A0A1B0GTG3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine biosynthesisKEGGhsa00220
Metabolic pathwaysKEGGhsa01100
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340020442022LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.11
340020442022LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.11
336192412021Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways.2
336192412021Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways.2
276337552016Identification and clinical significance of an elevated level of serum aminoacylase-1 autoantibody in patients with hepatitis B virus-related liver cirrhosis.8
276337552016Identification and clinical significance of an elevated level of serum aminoacylase-1 autoantibody in patients with hepatitis B virus-related liver cirrhosis.8
241170092014Aminoacylase I deficiency due to ACY1 mRNA exon skipping.8
248463012014Proteomics-based identification of the tumor suppressor role of aminoacylase 1 in hepatocellular carcinoma.13
241170092014Aminoacylase I deficiency due to ACY1 mRNA exon skipping.8
248463012014Proteomics-based identification of the tumor suppressor role of aminoacylase 1 in hepatocellular carcinoma.13
233175462013Overexpression of aminoacylase 1 is associated with colorectal cancer progression.10
237392322013Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation.16
233175462013Overexpression of aminoacylase 1 is associated with colorectal cancer progression.10
237392322013Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation.16
211282442011Differential aminoacylase expression in neuroblastoma.10

Citation

Dessen P

ACY1 (aminoacylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/570/acy1-(aminoacylase-1)