Identity
HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
MATE2,MATE2-B,MATE2-K,MATE2K
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 146802
MIM: 609833
HGNC: 26439
Ensembl: ENSG00000180638
Variants:
dbSNP: 146802
ClinVar: 146802
TCGA: ENSG00000180638
COSMIC: SLC47A2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000180638 | ENST00000325411 | Q86VL8 |
| ENSG00000180638 | ENST00000350657 | Q86VL8 |
| ENSG00000180638 | ENST00000433844 | C9JAE6 |
| ENSG00000180638 | ENST00000574239 | Q86VL8 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PK | PD | 21956618, 23267855, 23652408, 28834135 |
| PA450395 | metformin | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway | associated | PK | PD | 21956618, 22722338, 23267855, 23417334, 23652408, 24624919, 25939711, 28834135 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34383246 | 2021 | Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans. | 0 |
| 34383246 | 2021 | Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans. | 0 |
| 32708212 | 2020 | Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K. | 7 |
| 32708212 | 2020 | Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K. | 7 |
| 30951404 | 2019 | A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma. | 16 |
| 30951404 | 2019 | A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma. | 16 |
| 30433870 | 2018 | Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients. | 7 |
| 30433870 | 2018 | Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients. | 7 |
| 27821436 | 2017 | Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma. | 8 |
| 28131833 | 2017 | Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation. | 10 |
| 27821436 | 2017 | Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma. | 8 |
| 28131833 | 2017 | Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation. | 10 |
| 27178732 | 2016 | Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin. | 14 |
| 27271370 | 2016 | Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs. | 4 |
| 27959931 | 2016 | MATE2 Expression Is Associated with Cancer Cell Response to Metformin. | 19 |
Citation
Dessen P
SLC47A2 (solute carrier family 47 member 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/57011/slc47a2-(solute-carrier-family-47-member-2)
