NKX3-2 (NK3 homeobox 2)

2017-08-01  

Identity

HGNC
LOCATION
4p15.33
LOCUSID
ALIAS
BAPX1,NKX3.2,NKX3B,SMMD

Other Information

Locus ID:

NCBI: 579
MIM: 602183
HGNC: 951
Ensembl: ENSG00000109705

Variants:

dbSNP: 579
ClinVar: 579
TCGA: ENSG00000109705
COSMIC: NKX3-2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109705ENST00000382438P78367

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
351391062022BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner.0
351391062022BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner.0
297046862019A novel NKX3-2 mutation associated with perinatal lethal phenotype of spondylo-megaepiphyseal-metaphyseal dysplasia in a neonate.3
297046862019A novel NKX3-2 mutation associated with perinatal lethal phenotype of spondylo-megaepiphyseal-metaphyseal dysplasia in a neonate.3
297466012018Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.0
297466012018Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.0
283153342017Bapx1 mediates transforming growth factor-β- induced epithelial-mesenchymal transition and promotes a malignancy phenotype of gastric cancer cells.9
283153342017Bapx1 mediates transforming growth factor-β- induced epithelial-mesenchymal transition and promotes a malignancy phenotype of gastric cancer cells.9
273123412016A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.9
273123412016A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.9
262456912015BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.27
263634662015Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.6
262456912015BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.27
263634662015Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.6
225071292012Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.0

Citation

Dessen P

NKX3-2 (NK3 homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57013/nkx3-2-(nk3-homeobox-2)