COPB2 (COPI coat complex subunit beta 2)

2017-08-01  

Identity

HGNC
LOCATION
3q23
LOCUSID
ALIAS
MCPH19,beta-COP
FUSION GENES

Other Information

Locus ID:

NCBI: 9276
MIM: 606990
HGNC: 2232
Ensembl: ENSG00000184432

Variants:

dbSNP: 9276
ClinVar: 9276
TCGA: ENSG00000184432
COSMIC: COPB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184432ENST00000333188P35606
ENSG00000184432ENST00000503326H0YAC7
ENSG00000184432ENST00000507777P35606
ENSG00000184432ENST00000512153D6RBT6
ENSG00000184432ENST00000512242D6RCL6
ENSG00000184432ENST00000512309H0Y938
ENSG00000184432ENST00000513274D6RBG7
ENSG00000184432ENST00000514508D6RBZ7
ENSG00000184432ENST00000515006D6R997

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184345972008Coat-tether interaction in Golgi organization.41
203625472010Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.13
296742722018COPB2 promotes cell proliferation and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma cells.9
279861202016COPB2 Is Upregulated in Prostate Cancer and Regulates PC-3 Cell Proliferation, Cell Cycle, and Apoptosis.8
291296872018Coatomer subunit beta 2 (COPB2), identified by label-free quantitative proteomics, regulates cell proliferation and apoptosis in human prostate carcinoma cells.4
295092462018Downregulation of COPB2 by RNAi inhibits growth of human cholangiocellular carcinoma cells.4
309681462019Silencing of COPB2 inhibits the proliferation of gastric cancer cells and induces apoptosis via suppression of the RTK signaling pathway.4
299460452018Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen.2
316317862020MicroRNA-4461 derived from bone marrow mesenchymal stem cell exosomes inhibits tumorigenesis by downregulating COPB2 expression in colorectal cancer.1

Citation

Dessen P

COPB2 (COPI coat complex subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57020/copb2-(copi-coat-complex-subunit-beta-2)