ELOVL2 (ELOVL fatty acid elongase 2)

2017-08-01  

Identity

HGNC
LOCATION
6p24.2
LOCUSID
ALIAS
SSC2
FUSION GENES

Other Information

Locus ID:

NCBI: 54898
MIM: 611814
HGNC: 14416
Ensembl: ENSG00000197977

Variants:

dbSNP: 54898
ClinVar: 54898
TCGA: ENSG00000197977
COSMIC: ELOVL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197977ENST00000354666Q9NXB9
ENSG00000197977ENST00000354666A0A024QZV3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Fatty acid elongationKEGGko00062
Biosynthesis of unsaturated fatty acidsKEGGko01040
Fatty acid elongationKEGGhsa00062
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGhsa_M00415
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGM00415
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
alpha-linolenic (omega3) and linoleic (omega6) acid metabolismREACTOMER-HSA-2046104
alpha-linolenic acid (ALA) metabolismREACTOMER-HSA-2046106
Linoleic acid (LA) metabolismREACTOMER-HSA-2046105

References

Pubmed IDYearTitleCitations
200375892010A genome-wide perspective of genetic variation in human metabolism.252
191482762009Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.156
230617502012Methylation of ELOVL2 gene as a new epigenetic marker of age.99
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
254507872015Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science.21
298483542018Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.20
276721022017Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process.17
277881542016Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells.12
266334932015Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).8

Citation

Dessen P

ELOVL2 (ELOVL fatty acid elongase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57022/elovl2-(elovl-fatty-acid-elongase-2)