GAB3 (GRB2 associated binding protein 3)

2017-08-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
FUSION GENES

Other Information

Locus ID:

NCBI: 139716
MIM: 300482
HGNC: 17515
Ensembl: ENSG00000160219

Variants:

dbSNP: 139716
ClinVar: 139716
TCGA: ENSG00000160219
COSMIC: GAB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160219ENST00000369568Q8WWW8
ENSG00000160219ENST00000369575Q8WWW8
ENSG00000160219ENST00000424127Q8WWW8
ENSG00000160219ENST00000454973H7C3J9

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365459202023High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma.0
365459202023High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma.0
358225602022Identification of Grb2-associated binding protein 3 expression to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma.1
358225602022Identification of Grb2-associated binding protein 3 expression to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma.1
281151662017Gab3 is required for human colorectal cancer cell proliferation.5
282918202017Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation.6
281151662017Gab3 is required for human colorectal cancer cell proliferation.5
282918202017Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation.6
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
126401252003Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.22

Citation

Dessen P

GAB3 (GRB2 associated binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57025/gab3-(grb2-associated-binding-protein-3)