MIS18A (MIS18 kinetochore protein A)

2017-08-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
B28,C21orf45,C21orf46,FASP1,MIS18alpha,hMis18alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 54069
MIM: 618137
HGNC: 1286
Ensembl: ENSG00000159055

Variants:

dbSNP: 54069
ClinVar: 54069
TCGA: ENSG00000159055
COSMIC: MIS18A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159055ENST00000290130Q9NYP9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
336456312021Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.8
336456312021Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.8
314928602019Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing.25
314928602019Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing.25
276706102017Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes.2
280597022017CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.41
276706102017Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes.2
280597022017CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.41
269426802016Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.55
272390452016Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.35
269426802016Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.55
272390452016Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.35
171990382007Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.212
171990382007Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.212
158816662005P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1.0

Citation

Dessen P

MIS18A (MIS18 kinetochore protein A)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57034/mis18a-(mis18-kinetochore-protein-a)