Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 286257
MIM: 616315
HGNC: 27849
Ensembl: ENSG00000148362
Variants:
dbSNP: 286257
ClinVar: 286257
TCGA: ENSG00000148362
COSMIC: PAXX
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000148362 | ENST00000371620 | Q9BUH6 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37256950 | 2023 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. | 6 |
| 37256950 | 2023 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. | 6 |
| 31731258 | 2020 | Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. | 9 |
| 31731258 | 2020 | Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. | 9 |
| 30579708 | 2019 | Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53. | 13 |
| 30579708 | 2019 | Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53. | 13 |
| 30238427 | 2018 | PAXX Participates in Base Excision Repair via Interacting with Pol β and Contributes to TMZ Resistance in Glioma Cells. | 7 |
| 30250067 | 2018 | PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. | 16 |
| 30238427 | 2018 | PAXX Participates in Base Excision Repair via Interacting with Pol β and Contributes to TMZ Resistance in Glioma Cells. | 7 |
| 30250067 | 2018 | PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair. | 16 |
| 27705800 | 2016 | PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. | 55 |
| 27705800 | 2016 | PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. | 55 |
| 25574025 | 2015 | DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. | 163 |
| 25670504 | 2015 | Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. | 99 |
| 25574025 | 2015 | DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. | 163 |
Citation
Dessen P
PAXX (PAXX non-homologous end joining factor)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/57040/paxx-(paxx-non-homologous-end-joining-factor)
