Identity
HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
C6orf134,MEC17,Nbla00487,TAT,alpha-TAT,alpha-TAT1
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79969
MIM: 615556
HGNC: 21186
Ensembl: ENSG00000137343
Variants:
dbSNP: 79969
ClinVar: 79969
TCGA: ENSG00000137343
COSMIC: ATAT1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Cilium Assembly | REACTOME | R-HSA-5617833 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 31616045 | |
| PA445846 | Thrombocytopenia | Disease | ClinicalAnnotation | associated | PD | 31616045 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 31616045 | |
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | PD | 31616045 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38652325 | 2024 | The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases. | 2 |
| 38835115 | 2024 | Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ. | 0 |
| 38652325 | 2024 | The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases. | 2 |
| 38835115 | 2024 | Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ. | 0 |
| 34508164 | 2022 | αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion. | 5 |
| 34508164 | 2022 | αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion. | 5 |
| 34199510 | 2021 | Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. | 9 |
| 34199510 | 2021 | Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. | 9 |
| 29321169 | 2018 | The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. | 19 |
| 29869029 | 2018 | Dynamic localization of α-tubulin acetyltransferase ATAT1 through the cell cycle in human fibroblastic KD cells. | 6 |
| 30333138 | 2018 | GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking. | 15 |
| 29321169 | 2018 | The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. | 19 |
| 29869029 | 2018 | Dynamic localization of α-tubulin acetyltransferase ATAT1 through the cell cycle in human fibroblastic KD cells. | 6 |
| 30333138 | 2018 | GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking. | 15 |
| 27836544 | 2017 | Genetic disruption of tubulin acetyltransferase, αTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/β-catenin signaling. | 23 |
Citation
Dessen P
ATAT1 (alpha tubulin acetyltransferase 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/57048/atat1-(alpha-tubulin-acetyltransferase-1)
