METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
2017-08-01 AffiliationIdentity
HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
IME4,M6A,MT-A70,Spo8,hMETTL3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 56339
MIM: 612472
HGNC: 17563
Ensembl: ENSG00000165819
Variants:
dbSNP: 56339
ClinVar: 56339
TCGA: ENSG00000165819
COSMIC: METTL3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Processing of Capped Intron-Containing Pre-mRNA | REACTOME | R-HSA-72203 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36705430 | 2024 | METTL3 potentiates osteogenic differentiation of bone marrow mesenchymal stem cells via IGF2BP1/m6A/RUNX2. | 5 |
| 37249063 | 2024 | METTL3-mediated ALDH m(6)A methylation regulates the malignant behavior of BMI1(+) HNSCC stem cells. | 3 |
| 37619934 | 2024 | Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma. | 6 |
| 38013600 | 2024 | METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy. | 2 |
| 38018881 | 2024 | Methyltransferase-like 3-mediated m6A modification of miR-1908-5p contributes to nasopharyngeal carcinoma progression by targeting homeodomain-only protein homeobox. | 0 |
| 38030520 | 2024 | Mettl3-dependent m(6)A modification is essential for effector differentiation and memory formation of CD8(+) T cells. | 2 |
| 38030810 | 2024 | METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway. | 0 |
| 38043628 | 2024 | METTL3 regulates FAM83D m(6)A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway. | 2 |
| 38131226 | 2024 | Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review). | 0 |
| 38141906 | 2024 | METTL3 suppresses invasion of lung cancer via SH3BP5 m6A modification. | 0 |
| 38154356 | 2024 | METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer. | 2 |
| 38166703 | 2024 | The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target. | 2 |
| 38190128 | 2024 | FOXM1 Participates in Scleral Remodeling in Myopia by Upregulating APOA1 Expression Through METTL3/YTHDF2. | 0 |
| 38216561 | 2024 | FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation. | 2 |
| 38233403 | 2024 | METTL3 facilitates renal cell carcinoma progression by PLOD2 m(6)A-methylation under prolonged hypoxia. | 0 |
Citation
Dessen P
METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/57050/mettl3-(methyltransferase-3-n6-adenosine-methyltransferase-complex-catalytic-subunit)
